Linked Life Data

16584146

Source:http://linkedlifedata.com/resource/pubmed/id/16584146

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-4-4
pubmed:abstractText
The purpose of this research was to investigate the effects of different concentrations of polymer and sucrose stearate, aluminum tristearate as dispersing agents on microsphere properties and performance. The yield values of microspheres were over the 78%, and the encapsulation efficiencies were found to be approximately 73%. Particle sizes of microspheres prepared with aluminum tristearate were between 76 and 448 microm, while that of the microspheres containing sucrose stearate were between 521 and 2000 microm. Morphological and physicochemical properties of microspheres were investigated by scanning electron micrography and differential scanning calorimetry (DSC). DSC analysis indicated that verapamil hydrochloride formed a solid solution with acrylic polymers. In vitro release studies were performed using the flow-through cell method. While approximately 80% of drug was released from the microspheres containing aluminum tristearate in 480 minutes, the same amount of drug was released from microspheres containing sucrose stearate in only 60 minutes. Chemical structures and concentrations of the dispersing agents were clearly effective on the physical properties of microspheres and their drug-release characteristics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1530-9932
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E16
pubmed:dateRevised
2010-11-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Influence of aluminum tristearate and sucrose stearate as the dispersing agents on physical properties and release characteristics of eudragit RS microspheres.
pubmed:affiliation
Ankara University Faculty of Pharmacy, Department of Pharmaceutical tamer.baykara@pharmacy.ankara.edu.tr.
pubmed:publicationType
Journal Article