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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-12-10
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pubmed:abstractText |
A 40-year-old female suffering from recurrent migrainous strokes is reported. She did not show any muscle weakness or wasting. Ragged red and cytochrome c oxidase negative fibers were present in the muscle biopsy. Muscle mitochondrial DNA analysis showed a 5 kb deletion, without a point mutation at nucleotide pair 3243 in the mitochondrial tRNALeu(UUR) gene. Phosphorus nuclear magnetic resonance spectroscopy of brain and gastrocnemius muscle showed a defective energy metabolism in both organs. An increased inorganic phosphate to phosphocreatine ratio due to a decreased phosphocreatine content was found in the occipital lobes, while an abnormal work-energy cost transfer function and a low rate of phosphocreatine post-exercise recovery were found in the muscle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Electron Transport Complex IV,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer, Leu
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1658240-Adult,
pubmed-meshheading:1658240-Blotting, Southern,
pubmed-meshheading:1658240-Brain,
pubmed-meshheading:1658240-Chromosome Deletion,
pubmed-meshheading:1658240-DNA, Mitochondrial,
pubmed-meshheading:1658240-DNA Restriction Enzymes,
pubmed-meshheading:1658240-Electron Transport Complex IV,
pubmed-meshheading:1658240-Energy Metabolism,
pubmed-meshheading:1658240-Female,
pubmed-meshheading:1658240-Histocytochemistry,
pubmed-meshheading:1658240-Humans,
pubmed-meshheading:1658240-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1658240-Migraine Disorders,
pubmed-meshheading:1658240-Mitochondria, Muscle,
pubmed-meshheading:1658240-Muscles,
pubmed-meshheading:1658240-Oligodeoxyribonucleotides,
pubmed-meshheading:1658240-Phosphorus,
pubmed-meshheading:1658240-RNA, Ribosomal,
pubmed-meshheading:1658240-RNA, Transfer,
pubmed-meshheading:1658240-RNA, Transfer, Leu
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pubmed:year |
1991
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pubmed:articleTitle |
Muscle mitochondrial DNA deletion and 31P-NMR spectroscopy alterations in a migraine patient.
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pubmed:affiliation |
Istituto di Clinica Neurologica, Centro Dino Ferrari, Universita' degli Studi di Milano, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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