| pubmed-article:16581786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C0812201 | lld:lifeskim |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C0919488 | lld:lifeskim |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C0597304 | lld:lifeskim |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C1414377 | lld:lifeskim |
| pubmed-article:16581786 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:16581786 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16581786 | pubmed:dateCreated | 2006-4-3 | lld:pubmed |
| pubmed-article:16581786 | pubmed:abstractText | MEF is an ETS-related transcription factor with strong transcriptional activating activity that affects hematopoietic stem cell behavior and is required for normal NK cell and NK T-cell development. The MEF (also known as ELF4) gene is repressed by several leukemia-associated fusion transcription factor proteins (PML-retinoic acid receptor alpha and AML1-ETO), but it is also activated by retroviral insertion in several cancer models. We have previously shown that cyclin A-dependent phosphorylation of MEF largely restricts its activity to the G(1) phase of the cell cycle; we now show that MEF is a short-lived protein whose expression level also peaks during late G(1) phase. Mutagenesis studies show that the rapid turnover of MEF in S phase is dependent on the specific phosphorylation of threonine 643 and serine 648 at the C terminus of MEF by cdk2 and on the Skp1/Cul1/F-box (SCF) E3 ubiquitin ligase complex SCF(Skp2), which targets MEF for ubiquitination and proteolysis. Overexpression of MEF drives cells through the G(1)/S transition, thereby promoting cell proliferation. The tight regulation of MEF levels during the cell cycle contributes to its effects on regulating cell cycle entry and cell proliferation. | lld:pubmed |
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| pubmed-article:16581786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16581786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16581786 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16581786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16581786 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16581786 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:LiuYanY | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:NimerStephen... | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:KoffAndrewA | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:HedvatCyrus... | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:MaoShifengS | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:ZhuXin-HuaXH | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:NguyenHoangH | lld:pubmed |
| pubmed-article:16581786 | pubmed:author | pubmed-author:YaoJinjuanJ | lld:pubmed |
| pubmed-article:16581786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16581786 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:16581786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16581786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16581786 | pubmed:pagination | 3114-23 | lld:pubmed |
| pubmed-article:16581786 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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