1657876

Source:http://linkedlifedata.com/resource/pubmed/id/1657876

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001407, umls-concept:C0012854, umls-concept:C0017428, umls-concept:C0080194, umls-concept:C0392747, umls-concept:C0995575, umls-concept:C1504318, umls-concept:C1554963, umls-concept:C1710548
pubmed:issue	21
pubmed:dateCreated	1991-12-2
pubmed:abstractText	The genomic DNA of the marine nonheterocystous nitrogen-fixing cyanobacterium Trichodesmium sp. strain NIBB 1067 was found to be highly resistant to DNA restriction endonucleases. The DNA was digested extensively by the restriction enzyme DpnI, which requires adenine methylation for activity. The DNA composition, determined by high-performance liquid chromatography (HPLC), was found to be 69% AT. Surprisingly, it was found that a modified adenine which was not methylated at the usual N6 position was present and made up 4.7 mol% of the nucleosides in Trichodesmium DNA (15 mol% of deoxyadenosine). In order for adenine residues to be modified at this many positions, there must be many modifying enzymes or at least one of the modifying enzymes must have a degenerate recognition site. The reason(s) for this extensive methylation has not yet been determined but may have implications for the ecological success of this microorganism in nature.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-16348357, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-1938909, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-2172084, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-2513774, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-2819820, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-2832390, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-2854807, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-4897066, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-6094478, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-6254144, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-6262918, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-6298063, http://linkedlifedata.com/resource/pubmed/commentcorrection/1657876-6320895
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985120R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adenine, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial, http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0021-9193
pubmed:author	pubmed-author:FujitaYY, pubmed-author:LandryDD, pubmed-author:MannE CEC, pubmed-author:ZehrJ PJP
pubmed:issnType	Print
pubmed:volume	173
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	7059-62
pubmed:dateRevised	2010-9-10
pubmed:meshHeading	pubmed-meshheading:1657876-Adenine, pubmed-meshheading:1657876-Chromatography, High Pressure Liquid, pubmed-meshheading:1657876-Cyanobacteria, pubmed-meshheading:1657876-DNA, Bacterial, pubmed-meshheading:1657876-DNA Restriction Enzymes, pubmed-meshheading:1657876-Methylation
pubmed:year	1991
pubmed:articleTitle	Unique modification of adenine in genomic DNA of the marine cyanobacterium Trichodesmium sp. strain NIBB 1067.
pubmed:affiliation	Marine Sciences Research Center, State University of New York, Stony Brook 11794.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't