Linked Life Data

16578715

Source:http://linkedlifedata.com/resource/pubmed/id/16578715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-6-29
pubmed:abstractText
The unitary free energy of transfer of a hydrocarbon molecule from a hydrocarbon solvent to an aqueous medium is a measure of the hydrophobic interaction in the aqueous medium. We have reexamined available data on this phenomenon and have confirmed that the free energy for saturated hydrocarbons is proportional to the surface area of the cavity created by the solute in the aqueous solution, with the same proportionality constant for linear, branched, and cyclic hydrocarbon molecules. The numerical value of the proportionality constant is uncertain because absolute and self-consistent area measurements are not available. We estimate that it falls between 20 and 25 cal/mole per A(2) at 25 degrees (for areas measured at the distance of closest approach of water molecules), which is significantly less than the figure of 33 cal/mole per A(2) that has been assigned to the same parameter by Hermann [J. Phys. Chem. 76, 2754-2759 (1972)]. A small discrepancy exists when similar data for homologous series of alkyl derivatives are compared with results based on hydrocarbons themselves, and possible reasons for it are discussed.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2925-7
pubmed:dateRevised
2010-9-14
pubmed:year
1974
pubmed:articleTitle
Empirical correlation between hydrophobic free energy and aqueous cavity surface area.
pubmed:affiliation
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710.
pubmed:publicationType
Journal Article