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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1991-12-11
|
| pubmed:abstractText |
Kinetic modeling of the PET tracer 6-[18F]fluoro-L-dopa ([18F]Dopa), used to measure presynaptic dopamine function, requires the accurate determination of the plasma input curve. We have developed a new method that uses alumina extraction preceded by cation and anion exchange resins to determine the parent compound, [18F]Dopa and its critical metabolite 3-O-methyl-6-[18F]fluoro-L-dopa. Using this method we found that carbidopa increases the plasma input of [18F]Dopa while decreasing the rate of metabolite formation, and that previous drug treatment can significantly effect [18F]Dopa metabolism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0883-2889
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
847-54
|
| pubmed:dateRevised |
2009-6-4
|
| pubmed:meshHeading |
pubmed-meshheading:1657833-Animals,
pubmed-meshheading:1657833-Carbidopa,
pubmed-meshheading:1657833-Dihydroxyphenylalanine,
pubmed-meshheading:1657833-Dopamine,
pubmed-meshheading:1657833-Fluorine Radioisotopes,
pubmed-meshheading:1657833-Functional Laterality,
pubmed-meshheading:1657833-Kinetics,
pubmed-meshheading:1657833-MPTP Poisoning,
pubmed-meshheading:1657833-Macaca mulatta,
pubmed-meshheading:1657833-Reference Values,
pubmed-meshheading:1657833-Synapses,
pubmed-meshheading:1657833-Time Factors
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
New rapid analysis method demonstrates differences in 6-[18F] fluoro-L-dopa plasma input curves with and without carbidopa and in hemi-MPTP lesioned monkeys.
|
| pubmed:affiliation |
Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
|
| pubmed:publicationType |
Journal Article
|