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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1991-12-13
|
| pubmed:abstractText |
An ultrastructure study was carried out on the effect of a standard drug sodium stibogluconate and a newly identified active CDRI compound 87/305 [1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole] on amastigotes of Leishmania donovani in macrophage cells of spleen of infected hamsters. While Na-stibogluconate exerted its effect by activating the digestion capacity of host macrophages, compound 87/305 was directly lethal to the parasites without, exerting any effect on the host cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0971-5916
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
147-51
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1657768-Animals,
pubmed-meshheading:1657768-Antimony Sodium Gluconate,
pubmed-meshheading:1657768-Antiprotozoal Agents,
pubmed-meshheading:1657768-Cricetinae,
pubmed-meshheading:1657768-Leishmania donovani,
pubmed-meshheading:1657768-Leishmaniasis, Visceral,
pubmed-meshheading:1657768-Male,
pubmed-meshheading:1657768-Microscopy, Electron,
pubmed-meshheading:1657768-Pyrroles,
pubmed-meshheading:1657768-Spleen
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Ultrastructural study on the antileishmanial effect of 1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole in hamsters.
|
| pubmed:affiliation |
Division of Parasitology, Central Drug Research Institute, Lucknow.
|
| pubmed:publicationType |
Journal Article
|