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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-23
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pubmed:abstractText |
Interactions of nontypeable Haemophilus influenzae (NTHI) with macrophages are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the immunologic mechanisms that mediate NTHI-macrophage inflammation are poorly understood. Outer membrane protein (OMP) P6 and lipooligosaccharide (LOS) of NTHI are potent immunomodulators. We theorized that alveolar macrophages in COPD possess fundamental immune defects that permit NTHI to evade host responses.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-10071528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-10536303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-10988111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-10996579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-11173248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-11202064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-11292642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-11865419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-11934723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12010845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12096201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12106783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12181400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12200518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12360572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12522030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-12684248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-14561171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-14624669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15031800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15059784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15184206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15298554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15544629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15845475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-15888697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-16039021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-2451640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-3005225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-3497051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-3547567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-3549563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-381923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-6601684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16574934-9125549
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1535-4970
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16574934-Adult,
pubmed-meshheading:16574934-Aged,
pubmed-meshheading:16574934-Antigens, Bacterial,
pubmed-meshheading:16574934-Case-Control Studies,
pubmed-meshheading:16574934-Cell Culture Techniques,
pubmed-meshheading:16574934-Female,
pubmed-meshheading:16574934-Haemophilus influenzae,
pubmed-meshheading:16574934-Humans,
pubmed-meshheading:16574934-Interleukins,
pubmed-meshheading:16574934-Macrophages, Alveolar,
pubmed-meshheading:16574934-Male,
pubmed-meshheading:16574934-Middle Aged,
pubmed-meshheading:16574934-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:16574934-Smoking,
pubmed-meshheading:16574934-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
Impaired alveolar macrophage response to Haemophilus antigens in chronic obstructive lung disease.
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pubmed:affiliation |
Infectious Disease Division, Department of Veterans Affairs Western New York Healthcare System, State University of New York at Buffalo School of Medicine, Buffalo, NY 14215, USA. berenson@acsu.buffalo.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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