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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-5-19
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pubmed:abstractText |
Cholesteryl ester transfer protein (CETP) inhibition with torcetrapib not only increases high-density lipoprotein cholesterol levels but also significantly reduces plasma triglyceride, low-density lipoprotein (LDL) cholesterol, and apolipoprotein B (apoB) levels. The goal of the present study was to define the kinetic mechanism(s) by which CETP inhibition reduces levels of apoB-containing lipoproteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/CETP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Ester Transfer Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, IDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/torcetrapib
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:BarrettP Hugh RPH,
pubmed-author:BrousseauMargaret EME,
pubmed-author:DiffenderferMargaret RMR,
pubmed-author:DigenioAndres GAG,
pubmed-author:DolnikowskiGregory GGG,
pubmed-author:FaruqiAishaA,
pubmed-author:MancusoJames PJP,
pubmed-author:MillarJohn SJS,
pubmed-author:NartsuphaChorthipC,
pubmed-author:RaderDaniel JDJ,
pubmed-author:SchaeferErnst JEJ,
pubmed-author:WeltyFrancine KFK,
pubmed-author:WolfeMegan LML
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1350-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16574893-Adult,
pubmed-meshheading:16574893-Aged,
pubmed-meshheading:16574893-Apolipoprotein B-100,
pubmed-meshheading:16574893-Apolipoproteins B,
pubmed-meshheading:16574893-Carrier Proteins,
pubmed-meshheading:16574893-Cholesterol Ester Transfer Proteins,
pubmed-meshheading:16574893-Cross-Over Studies,
pubmed-meshheading:16574893-Drug Synergism,
pubmed-meshheading:16574893-Glycoproteins,
pubmed-meshheading:16574893-Heptanoic Acids,
pubmed-meshheading:16574893-Humans,
pubmed-meshheading:16574893-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:16574893-Kinetics,
pubmed-meshheading:16574893-Lipids,
pubmed-meshheading:16574893-Lipoproteins,
pubmed-meshheading:16574893-Lipoproteins, IDL,
pubmed-meshheading:16574893-Lipoproteins, LDL,
pubmed-meshheading:16574893-Lipoproteins, VLDL,
pubmed-meshheading:16574893-Middle Aged,
pubmed-meshheading:16574893-Pyrroles,
pubmed-meshheading:16574893-Quinolines,
pubmed-meshheading:16574893-Single-Blind Method
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pubmed:year |
2006
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pubmed:articleTitle |
Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism in humans.
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pubmed:affiliation |
Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. jsmillar@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, N.I.H., Extramural
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