| pubmed-article:16572896 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C0007131 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16572896 | lifeskim:mentions | umls-concept:C1548818 | lld:lifeskim |
| pubmed-article:16572896 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16572896 | pubmed:dateCreated | 2006-3-31 | lld:pubmed |
| pubmed-article:16572896 | pubmed:abstractText | Exposure of human non-small cell lung cancer cells (NCI-H460) to gradually increasing concentrations of doxorubicin resulted in the appearance of a new cell line (NCI-H460/R) that was resistant to doxorubicin (96.2-fold) and cross-resistant to etoposide, paclitaxel, vinblastine and epirubicin. Slight cross-resistance to two MDR-unrelated drugs 8-Cl-cAMP and sulfinosine was observed. Flow cytometry analysis showed that the accumulation of doxorubicin in the resistant cells was 88.4% lower than in the parental cells. Also, verapamil significantly decreased the efflux rate in NCI-H460 and NCI-H460/R cells, whereas curcumin inhibited the efflux in NCI-H460 cells only. Gene expression data confirmed the induction of mdr1 (P-gp), as judged by the observed 15-fold increase in its mRNA concentration in doxorubicin-resistant NCI-H460/R cells. In contrast, mrp1 and lrp expression was unaffected by the doxorubicin resistance. Further work should develop a rationale for a novel treatment of NSCLC with appropriate modulators of resistance aimed at improving the outcome of the acquired drug resistance. | lld:pubmed |
| pubmed-article:16572896 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16572896 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16572896 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16572896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16572896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16572896 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16572896 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16572896 | pubmed:issn | 1120-009X | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:RakicLL | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:JankovicDD | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:RuzdijicSS | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:KanazirSS | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:MarkovicI DID | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:PesicMM | lld:pubmed |
| pubmed-article:16572896 | pubmed:author | pubmed-author:MarkovicJ ZJZ | lld:pubmed |
| pubmed-article:16572896 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16572896 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:16572896 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16572896 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16572896 | pubmed:pagination | 66-73 | lld:pubmed |
| pubmed-article:16572896 | pubmed:dateRevised | 2009-8-4 | lld:pubmed |
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| pubmed-article:16572896 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16572896 | pubmed:articleTitle | Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs. | lld:pubmed |
| pubmed-article:16572896 | pubmed:affiliation | Institute for Biological Research, Department of Neurobiology and Immunology, Laboratory of Molecular Neurobiology, Belgrade, Serbia & Montenegro. | lld:pubmed |
| pubmed-article:16572896 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16572896 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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