Source:http://linkedlifedata.com/resource/pubmed/id/16571841
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-3-30
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| pubmed:abstractText |
We examined the genetic associations of the G-2548A polymorphism in the promoter of the leptin (LEP) gene and the Gln223Arg (Q223R) polymorphism of the leptin receptor (LEPR) gene with obesity. Two hundred twenty-six obese aboriginal subjects (BMI > or = 27 kg/m2) and 182 aboriginal subjects with normal weight (BMI < 25 kg/m2) participated in this study. The polymorphisms of LEP G-2548A and LEPR Q223R were genotyped by polymerase chain reaction/restriction fragment length polymorphism, and their anthropometric characteristics were measured. Levels of leptin, triglycerides, and cholesterol were measured after overnight fasting. We found that the frequencies of the LEP G/G homozygote (22.6%) with Mendelian recessive (chi2 = 7.89, p = 0.005) and codominant (chi2 = 7.93, p = 0.02) models to be higher in the extremely obese subjects (BMI > or = 35 kg/m2) than in normal weight subjects (6.9%) but not in moderately obese subjects (35 > BMI > or = 27 kg/m2). There was no difference in genotypic frequency of the LEPR Q223R polymorphism between the extreme obese and control groups. We suggest that the LEP -2548 G/G homozygote plays a genetic recessive role in the development of extreme obesity in Taiwanese aborigines.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, human
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1930-7381
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
183-7
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| pubmed:dateRevised |
2008-1-21
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| pubmed:meshHeading |
pubmed-meshheading:16571841-Asian Continental Ancestry Group,
pubmed-meshheading:16571841-Body Mass Index,
pubmed-meshheading:16571841-Case-Control Studies,
pubmed-meshheading:16571841-Cholesterol,
pubmed-meshheading:16571841-Female,
pubmed-meshheading:16571841-Gene Frequency,
pubmed-meshheading:16571841-Genotype,
pubmed-meshheading:16571841-Humans,
pubmed-meshheading:16571841-Leptin,
pubmed-meshheading:16571841-Male,
pubmed-meshheading:16571841-Middle Aged,
pubmed-meshheading:16571841-Obesity,
pubmed-meshheading:16571841-Obesity, Morbid,
pubmed-meshheading:16571841-Polymerase Chain Reaction,
pubmed-meshheading:16571841-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:16571841-Receptors, Cell Surface,
pubmed-meshheading:16571841-Receptors, Leptin,
pubmed-meshheading:16571841-Taiwan,
pubmed-meshheading:16571841-Triglycerides
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| pubmed:year |
2006
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| pubmed:articleTitle |
G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines.
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| pubmed:affiliation |
Faculty of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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