Linked Life Data

16570100

Source:http://linkedlifedata.com/resource/pubmed/id/16570100

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-3-29
pubmed:abstractText
The CB1 cannabinoid receptor has attracted much recent interest because of the observation that CB1 receptor antagonists have efficacy in treating metabolic syndrome and obesity. CB1 receptors also mediate most of the psychotropic effects of Delta9-tetrahydrocannabinol (Delta9THC), the principal psychoactive component of cannabis. In addition, they are one component of an interesting and widespread paracrine signaling system, the endocannabinoid system. The endocannabinoid system is comprised of cannabinoid receptors, endogenous cannabinoids, and the metabolic pathways responsible for their synthesis and degradation. The details of the endocannabinoid system have been most thoroughly studied in the brain. Here it has been shown to be intimately involved in several forms of neuronal plasticity. That is, activation of CB1 receptors by endocannabinoids produces either short- or long-term changes in the efficacy of synaptic transmission. The behavioral consequences of these changes are many, but some of the most striking and relevant to the current symposium are those associated with endogenous reward and consumptive behavior.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0307-0565
pubmed:author
pubmed:issnType
Print
pubmed:volume
30 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S19-23
pubmed:dateRevised
2009-9-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Mechanisms of CB1 receptor signaling: endocannabinoid modulation of synaptic strength.
pubmed:affiliation
Department of Anesthesiology, University of Washington School of Medicine, Seattle, WA 98195-6540, USA. kmackie@u.washington.edu
pubmed:publicationType
Journal Article, Review