|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-3-28
|
|
pubmed:abstractText |
Metal plates for internal fixation of fractures have been used for more than 100 years. Although initial shortcomings such as corrosion and insufficient strength have been overcome, more recent designs have not solved all problems. Further research is needed to develop a plate that accelerates fracture healing while not interfering with bone physiology. The introduction of rigid plates had by far the greatest impact on plate fixation of fractures. However, it led to cortical porosis, delayed bridging, and refractures after plate removal. These unwarranted effects were said to be caused by bone-plate contact interfering with cortical perfusion. Consequently, further plate modifications aimed to reduce this contact area to minimize necrosis and subsequent porosis. The advocates of limited-contact plates have not published measurements of the contact area or proof of the temporary nature of the porosis. Moreover, clinical studies of newer plate types have failed to show a superior outcome. Histomor-phometric measurements of the cortex showed no difference in the extent of necrosis under plates having different contact areas. Necrosis was predominant in the periosteal cortical half, whereas porosis occurred mostly in the endosteal cortical half. No positive correlation was found between either. The scientific evidence to date strongly suggests that bone loss is caused by stress shielding and not interference with cortical perfusion secondary to bone-plate contact. Consequently, an axially compressible plate (ACP) incorporating polylactide (PLA) inserts press-fit around screw holes was designed. The bioresorbable inserts should allow for (1) increased micromotion in the axial plane to promote healing during the union phase and (2) gradual degradation over time to decrease stress shielding during the remodeling phase. Results of ongoing experimental results are encouraging. Only plates allowing dynamic compression in the axial plane can lead to a revolution in fracture fixation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-10206249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-1091653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-11186403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-12463652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-12665968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-13521188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-14668503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-1549332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-1562432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-18921624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-2073446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-2403497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-2557719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-2918001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-3289811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-4030869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-5057109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-5133037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-681422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-6822605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-7263759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-7929498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-8745801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-89107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-8994558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-9186225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-9294802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16568382-952210
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0949-2658
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
118-26
|
|
pubmed:dateRevised |
2010-9-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16568382-Animals,
pubmed-meshheading:16568382-Biocompatible Materials,
pubmed-meshheading:16568382-Bone Plates,
pubmed-meshheading:16568382-Clinical Trials as Topic,
pubmed-meshheading:16568382-Disease Models, Animal,
pubmed-meshheading:16568382-Fracture Fixation, Internal,
pubmed-meshheading:16568382-Fracture Healing,
pubmed-meshheading:16568382-Humans,
pubmed-meshheading:16568382-Internal Fixators,
pubmed-meshheading:16568382-Materials Testing,
pubmed-meshheading:16568382-Prosthesis Design,
pubmed-meshheading:16568382-Prosthesis Failure,
pubmed-meshheading:16568382-Risk Factors,
pubmed-meshheading:16568382-Sensitivity and Specificity,
pubmed-meshheading:16568382-Stress, Mechanical
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Internal plate fixation of fractures: short history and recent developments.
|
|
pubmed:affiliation |
Bone and Joint Research Laboratory, Faculty of Medicine, Division of Orthopaedic Surgery, University of Ottawa, 1321-451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Review
|
