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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-4-19
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pubmed:abstractText |
Traditional genetic approaches to identify gene mutations in cancer are expensive and laborious. Nonetheless, if we are to avoid rejecting effective molecular targeted therapies, we must test these drugs in patients whose tumors harbor mutations in the drug target. We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:AdesinaAdekunleA,
pubmed-author:AshleyDavid MDM,
pubmed-author:ChintagumpalaMuraliM,
pubmed-author:CurranTomT,
pubmed-author:DaltonJamesJ,
pubmed-author:FinkelsteinDavidD,
pubmed-author:FullerChristineC,
pubmed-author:GajjarAmarA,
pubmed-author:GilbertsonRichard JRJ,
pubmed-author:HoggTwala LTL,
pubmed-author:KellieStewart JSJ,
pubmed-author:LauChing CCC,
pubmed-author:TaylorMichael DMD,
pubmed-author:ThompsonMargaret CMC
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pubmed:issnType |
Electronic
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pubmed:day |
20
|
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pubmed:volume |
24
|
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1924-31
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16567768-Adolescent,
pubmed-meshheading:16567768-Adult,
pubmed-meshheading:16567768-Antineoplastic Agents,
pubmed-meshheading:16567768-Cerebellar Neoplasms,
pubmed-meshheading:16567768-Child,
pubmed-meshheading:16567768-Child, Preschool,
pubmed-meshheading:16567768-Cost-Benefit Analysis,
pubmed-meshheading:16567768-DNA Mutational Analysis,
pubmed-meshheading:16567768-Female,
pubmed-meshheading:16567768-Gene Expression Profiling,
pubmed-meshheading:16567768-Genomics,
pubmed-meshheading:16567768-Humans,
pubmed-meshheading:16567768-Immunohistochemistry,
pubmed-meshheading:16567768-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16567768-Infant,
pubmed-meshheading:16567768-Infant, Newborn,
pubmed-meshheading:16567768-Male,
pubmed-meshheading:16567768-Medulloblastoma,
pubmed-meshheading:16567768-Patient Selection,
pubmed-meshheading:16567768-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2006
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pubmed:articleTitle |
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
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pubmed:affiliation |
St Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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