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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-4-17
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pubmed:abstractText |
Thyroid hormone-mediated positive cardiotropic effects are differently regulated between the atria and ventricles. This regulation is, at least in part, dependent on sarcoplasmic reticulum (SR) proteins. Sarcolipin, a homologue of phospholamban, has been recently identified as an atrium-specific SR protein. The expression of sarcolipin mRNA was significantly decreased in the atria of mice with hyperthyroidism and in 3,5,3'-triiodo-l-thyronine-treated neonatal rat atrial myocytes. Promoter activity and mRNA stability analyses revealed that thyroid hormone post-transcriptionally down regulated the expression of sarcolipin mRNA. The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
pubmed-author:BaiYunzheY,
pubmed-author:HoriHideakiH,
pubmed-author:InoueKazuhideK,
pubmed-author:IshikawaYoshihiroY,
pubmed-author:MinamisawaSusumuS,
pubmed-author:MochizukiSeibuS,
pubmed-author:NakagomeMasamichiM,
pubmed-author:SatoYojiY,
pubmed-author:ShimizuMitsuyukiM,
pubmed-author:UemuraNobuyukiN,
pubmed-author:YamaguchiTeruhideT,
pubmed-author:YokoyamaUtakoU
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
580
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2247-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16566928-Animals,
pubmed-meshheading:16566928-Calcium-Binding Proteins,
pubmed-meshheading:16566928-Cell Line,
pubmed-meshheading:16566928-Down-Regulation,
pubmed-meshheading:16566928-Heart Atria,
pubmed-meshheading:16566928-Hyperthyroidism,
pubmed-meshheading:16566928-Mice,
pubmed-meshheading:16566928-Muscle Proteins,
pubmed-meshheading:16566928-Myocardium,
pubmed-meshheading:16566928-Myocytes, Cardiac,
pubmed-meshheading:16566928-Promoter Regions, Genetic,
pubmed-meshheading:16566928-Proteolipids,
pubmed-meshheading:16566928-RNA, Messenger,
pubmed-meshheading:16566928-RNA Stability,
pubmed-meshheading:16566928-Rats,
pubmed-meshheading:16566928-Sequence Homology, Amino Acid,
pubmed-meshheading:16566928-Transcription, Genetic,
pubmed-meshheading:16566928-Triiodothyronine
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pubmed:year |
2006
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pubmed:articleTitle |
Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium.
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pubmed:affiliation |
Department of Physiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. sminamis@med.yokohama-cu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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