| pubmed-article:16565724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16565724 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:16565724 | lifeskim:mentions | umls-concept:C1384617 | lld:lifeskim |
| pubmed-article:16565724 | lifeskim:mentions | umls-concept:C0036503 | lld:lifeskim |
| pubmed-article:16565724 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:16565724 | lifeskim:mentions | umls-concept:C0475311 | lld:lifeskim |
| pubmed-article:16565724 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16565724 | pubmed:dateCreated | 2006-4-6 | lld:pubmed |
| pubmed-article:16565724 | pubmed:abstractText | We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors. | lld:pubmed |
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| pubmed-article:16565724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16565724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16565724 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16565724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16565724 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16565724 | pubmed:issn | 1078-8956 | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:WattFiona MFM | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:ZouboulisChri... | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:LyleStephenS | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:TakedaHikaruH | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:SmythIanI | lld:pubmed |
| pubmed-article:16565724 | pubmed:author | pubmed-author:LazarAlexande... | lld:pubmed |
| pubmed-article:16565724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16565724 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:16565724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16565724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16565724 | pubmed:pagination | 395-7 | lld:pubmed |
| pubmed-article:16565724 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16565724 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16565724 | pubmed:articleTitle | Human sebaceous tumors harbor inactivating mutations in LEF1. | lld:pubmed |
| pubmed-article:16565724 | pubmed:affiliation | Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. | lld:pubmed |
| pubmed-article:16565724 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16565724 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16565724 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16565724 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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