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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-4-6
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pubmed:abstractText |
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
395-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16565724-Adenoma,
pubmed-meshheading:16565724-Alleles,
pubmed-meshheading:16565724-Amino Acid Sequence,
pubmed-meshheading:16565724-Amino Acid Substitution,
pubmed-meshheading:16565724-Base Sequence,
pubmed-meshheading:16565724-Cell Line,
pubmed-meshheading:16565724-Conserved Sequence,
pubmed-meshheading:16565724-DNA,
pubmed-meshheading:16565724-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16565724-Genes, Reporter,
pubmed-meshheading:16565724-Genetic Markers,
pubmed-meshheading:16565724-Humans,
pubmed-meshheading:16565724-Luciferases,
pubmed-meshheading:16565724-Lymphoid Enhancer-Binding Factor 1,
pubmed-meshheading:16565724-Molecular Sequence Data,
pubmed-meshheading:16565724-Sebaceous Gland Neoplasms,
pubmed-meshheading:16565724-Sequence Analysis, DNA,
pubmed-meshheading:16565724-Sequence Homology, Amino Acid,
pubmed-meshheading:16565724-Signal Transduction,
pubmed-meshheading:16565724-Transcription, Genetic,
pubmed-meshheading:16565724-Transcriptional Activation,
pubmed-meshheading:16565724-Wnt Proteins,
pubmed-meshheading:16565724-beta Catenin
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pubmed:year |
2006
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pubmed:articleTitle |
Human sebaceous tumors harbor inactivating mutations in LEF1.
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pubmed:affiliation |
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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