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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1991-11-4
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pubmed:abstractText |
Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This increase is paralleled by an increase in the transcription rate of the proto-oncogene encoding the AP-1 component, c-Jun resulting in an increase in c-Jun protein in infected cells. The increased AP-1 activity in infected cells is dependent upon the HSV immediate-early protein ICPO. Thus a mutant lacking the gene encoding this protein fails to increase AP-1 activity whilst an ICPO expression plasmid can specifically increase the activity of an AP-1 dependent promoter in co-transfection experiments. The implications of these effects in the interaction of HSV with cultured cells are discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-14468055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-1689075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-1826351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-1846781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-196289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-212585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2155637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2157053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-219222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2457172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2535908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2821506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2822840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2825588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2830989,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2842713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-2845125,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1656381-6828386
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4879-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1656381-Binding Sites,
pubmed-meshheading:1656381-Blotting, Western,
pubmed-meshheading:1656381-Cell Line,
pubmed-meshheading:1656381-Gene Expression,
pubmed-meshheading:1656381-HeLa Cells,
pubmed-meshheading:1656381-Humans,
pubmed-meshheading:1656381-Immediate-Early Proteins,
pubmed-meshheading:1656381-Mutation,
pubmed-meshheading:1656381-Plasmids,
pubmed-meshheading:1656381-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:1656381-Simplexvirus,
pubmed-meshheading:1656381-Transfection,
pubmed-meshheading:1656381-Ubiquitin-Protein Ligases,
pubmed-meshheading:1656381-Viral Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.
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pubmed:affiliation |
Department of Biochemistry, University College and Middlesex School of Medicine, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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