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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-9-4
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pubmed:abstractText |
Regulatory and competitive pressure to reduce the QT interval prolongation risk of potential new drugs has led to focus on methods to test for inhibition of the human ether-a-go-go-related gene (hERG)-encoded K+ channel, the primary molecular target underlying this safety issue. Here we describe the validation of a method that combines medium-throughput with direct assessment of channel function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1056-8719
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pubmed:author |
pubmed-author:Abi-GergesNN,
pubmed-author:AlbertsonNN,
pubmed-author:Bridgland-TaylorM HMH,
pubmed-author:DavisA MAM,
pubmed-author:DingMM,
pubmed-author:EasterAA,
pubmed-author:HammondT GTG,
pubmed-author:HargreavesA CAC,
pubmed-author:HeapyC GCG,
pubmed-author:HenthornD CDC,
pubmed-author:JacobsonII,
pubmed-author:OrmeAA,
pubmed-author:PerssonFF,
pubmed-author:PollardC ECE,
pubmed-author:SmallB GBG,
pubmed-author:SullivanEE,
pubmed-author:SullivanMM,
pubmed-author:ValentinJ-PJP
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-99
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pubmed:dateRevised |
2008-10-28
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pubmed:meshHeading |
pubmed-meshheading:16563806-Animals,
pubmed-meshheading:16563806-CHO Cells,
pubmed-meshheading:16563806-Cell Line,
pubmed-meshheading:16563806-Cricetinae,
pubmed-meshheading:16563806-Electrophysiology,
pubmed-meshheading:16563806-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:16563806-Humans,
pubmed-meshheading:16563806-Patch-Clamp Techniques,
pubmed-meshheading:16563806-Potassium Channel Blockers,
pubmed-meshheading:16563806-Reproducibility of Results,
pubmed-meshheading:16563806-Rubidium
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pubmed:articleTitle |
Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.
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pubmed:affiliation |
Safety Assessment UK, AstraZeneca R&D Alderley Park, Macclesfield, SK10 4TG, UK.
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pubmed:publicationType |
Journal Article
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