|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1991-11-5
|
|
pubmed:abstractText |
In the Xenopus central nervous system the binding sites for [3H]kainate and [3H]alpha-amino-3-hydroxy-5-methylisoxazolepropionate [( 3H]AMPA) are highly localised and the distributions of both ligands are largely coincident. The telencephalon was the most strongly labelled area with a relatively uniform distribution of binding sites. In addition, the infundibulum and the cerebellum were also heavily labelled. Areas containing a lower density of binding sites included the septum, the thalamus and the optic lobes. [3H]Kainate binding was potently inhibited by 1 microM AMPA in the presence of 0.1 M KSCN and [3H]AMPA binding was blocked by 1 microM kainate. These data are consistent with the hypothesis that kainate and AMPA bind to the same site on a single protein entity and that this unitary AMPA/KA binding protein may constitute the predominant type of excitatory amino acid receptor in the Xenopus brain.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
129
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
35-8
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:1656338-Animals,
pubmed-meshheading:1656338-Autoradiography,
pubmed-meshheading:1656338-Binding Sites,
pubmed-meshheading:1656338-Brain Chemistry,
pubmed-meshheading:1656338-Ibotenic Acid,
pubmed-meshheading:1656338-Kainic Acid,
pubmed-meshheading:1656338-N-Methylaspartate,
pubmed-meshheading:1656338-Receptors, Glutamate,
pubmed-meshheading:1656338-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1656338-Receptors, Neurotransmitter,
pubmed-meshheading:1656338-Xenopus,
pubmed-meshheading:1656338-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Autoradiographic localisations of glutamatergic ligand binding sites in Xenopus brain.
|
|
pubmed:affiliation |
Department of Pharmacology, Medical School, University of Birmingham, U.K.
|
|
pubmed:publicationType |
Journal Article
|
