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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0028630,
umls-concept:C0034790,
umls-concept:C0085112,
umls-concept:C0162326,
umls-concept:C0205144,
umls-concept:C0439097,
umls-concept:C0441587,
umls-concept:C0442802,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
4
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pubmed:dateCreated |
1991-11-1
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pubmed:abstractText |
The severe combined immunodeficiency (SCID) mutation has been postulated to affect a V(D)J recombinase activity involved in coding joint formation. Analysis of 38 joints from 34 distinct sequences of normally rearranged T cell receptor (TCR) gamma and delta genes from adult, SCID thymocytes reveals coding joints with an increased number of P nucleotides. One-third of P sequences are greater than or equal to 4 nucleotides in length and P elements of up to 15 bases are observed. This suggests that the SCID defect deregulates P nucleotide addition. Consequently, essential V(D)J recombination intermediates may seldom be generated.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2112584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2136898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2156708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2215662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2317864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2439914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2522971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2590942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2594068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2785917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2805800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2847872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2961997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-2963227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3016509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3017705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3025650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3093081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3135329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3135938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3145241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3167977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3344222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3397543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3486721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3653075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-3917858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-6287467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-6817142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1655945-6823332
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
769-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1655945-Animals,
pubmed-meshheading:1655945-Base Sequence,
pubmed-meshheading:1655945-DNA,
pubmed-meshheading:1655945-DNA Nucleotidyltransferases,
pubmed-meshheading:1655945-DNA Transposable Elements,
pubmed-meshheading:1655945-Mice,
pubmed-meshheading:1655945-Mice, Mutant Strains,
pubmed-meshheading:1655945-Molecular Sequence Data,
pubmed-meshheading:1655945-Oligodeoxyribonucleotides,
pubmed-meshheading:1655945-Polymerase Chain Reaction,
pubmed-meshheading:1655945-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:1655945-Severe Combined Immunodeficiency,
pubmed-meshheading:1655945-T-Lymphocytes,
pubmed-meshheading:1655945-VDJ Recombinases
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pubmed:year |
1991
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pubmed:articleTitle |
T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.
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pubmed:affiliation |
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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