Linked Life Data

16558088

Source:http://linkedlifedata.com/resource/pubmed/id/16558088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-6-29
pubmed:abstractText
The immunogenicity of leptospiral whole cell (WC) and outer envelope (OE) vaccines from virulent and avirulent strains was compared in hamsters. The 50% protective dose against death (PD(50D)) and kidney infection (PD(50K)) was evaluated for serotypes icterohaemorrhagiae, canicola, pomona, and grippotyphosa. The OE and WC of virulent strains possessed greater immunogenicity than the OE and WC of avirulent strains. More vaccine (<0.1 to 11.0 mug [dry weight] per hamster) was required for the PD(50K) than for the PD(50D) (<0.1 to 1.7 mug [dry weight] per hamster). The OE from virulent strains of these four serotypes plus hardjo were combined to form a pentavalent OE vaccine which proved to be satisfactory in immunogenic potency. Duration of immunity was not evaluated.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Nov
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1051-6
pubmed:dateRevised
2010-9-14
pubmed:year
1974
pubmed:articleTitle
Immunogenicity of whole cell and outer envelope leptospiral vaccines in hamsters.
pubmed:affiliation
Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455.
pubmed:publicationType
Journal Article