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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-3-30
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pubmed:abstractText |
A 95% ethanol extract from whole aerial parts of Euphorbia hirta (EH A001) showed antihistaminic, antiinflammatory and immunosuppressive properties in various animal models. EH A001 inhibited rat peritoneal mast cell degranulation triggered by compound 48/80. It significantly inhibited dextran-induced rat paw edema. EH A001 prevented eosinophil accumulation and eosinophil peroxidase activity and reduced the protein content in bronchoalveolar lavage fluid (BALF) in a 'mild' model of asthma. Moreover, the CD4/CD8 ratio in peripheral blood was suppressed. EH A001 attenuated the release of interleukin-4 (IL-4) and augmented interferon-gamma (IFN-gamma) in ovalbumin-sensitized mouse splenocytes. The results were compared with the effects of known compounds, ketotifen, cetirizine and cyclophosphamide. These findings demonstrated that Euphorbia hirta possessed significant activity to prevent early and late phase allergic reactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0951-418X
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pubmed:author |
pubmed-author:BaniSS,
pubmed-author:JohriR KRK,
pubmed-author:KaiserPP,
pubmed-author:KapahiB KBK,
pubmed-author:KhajuriaAA,
pubmed-author:KoulAA,
pubmed-author:SattiN KNK,
pubmed-author:SinghG DGD,
pubmed-author:SinghSS,
pubmed-author:SuriK AKA,
pubmed-author:YoussoufM SMS
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pubmed:copyrightInfo |
Copyright 2006 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
316-21
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pubmed:meshHeading |
pubmed-meshheading:16557622-Animals,
pubmed-meshheading:16557622-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:16557622-CD4-CD8 Ratio,
pubmed-meshheading:16557622-Cytokines,
pubmed-meshheading:16557622-Edema,
pubmed-meshheading:16557622-Eosinophil Peroxidase,
pubmed-meshheading:16557622-Eosinophils,
pubmed-meshheading:16557622-Euphorbia,
pubmed-meshheading:16557622-Histamine Antagonists,
pubmed-meshheading:16557622-Hypersensitivity,
pubmed-meshheading:16557622-Leukocyte Count,
pubmed-meshheading:16557622-Male,
pubmed-meshheading:16557622-Mice,
pubmed-meshheading:16557622-Mice, Inbred BALB C,
pubmed-meshheading:16557622-Ovalbumin,
pubmed-meshheading:16557622-Plant Extracts,
pubmed-meshheading:16557622-Rats,
pubmed-meshheading:16557622-Rats, Wistar,
pubmed-meshheading:16557622-Spleen
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibition of early and late phase allergic reactions by Euphorbia hirta L.
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pubmed:affiliation |
Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, Jammu-Tawi 180 001, India.
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pubmed:publicationType |
Journal Article
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