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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
27
|
| pubmed:dateCreated |
1991-10-29
|
| pubmed:databankReference | |
| pubmed:abstractText |
By regulating transmembrane Na+ and K+ concentrations and membrane potential, the Na+,K(+)-ATPase plays an important role in regulating cardiac, skeletal, and smooth muscle function. A high degree of amino acid sequence and structural identity characterizes the three Mr 100,000 Na+,K(+)-ATPase alpha subunit isoforms expressed in cardiac and skeletal muscle. Strikingly, vascular smooth muscle utilizes alternative RNA processing of the alpha-1 gene to express a structurally distinct Mr approximately 65,000 isoform, alpha 1-T (truncated). Analysis of both its mRNA and protein structure reveals that alpha-1-T represents a major, evolutionarily conserved, truncated Na+,K(+)-ATPase isoform expressed in vascular smooth muscle. This demonstrates an unexpected complexity in the regulation of vascular smooth muscle Na+,K(+)-ATPase gene expression and suggests that a structurally novel, truncated alpha subunit may play a role in vascular smooth muscle active ion transport.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
266
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
18308-12
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1655743-Amino Acid Sequence,
pubmed-meshheading:1655743-Animals,
pubmed-meshheading:1655743-Base Sequence,
pubmed-meshheading:1655743-Blotting, Northern,
pubmed-meshheading:1655743-Blotting, Western,
pubmed-meshheading:1655743-Cell Membrane,
pubmed-meshheading:1655743-DNA,
pubmed-meshheading:1655743-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:1655743-Isoenzymes,
pubmed-meshheading:1655743-Membrane Potentials,
pubmed-meshheading:1655743-Molecular Sequence Data,
pubmed-meshheading:1655743-Muscle, Smooth, Vascular,
pubmed-meshheading:1655743-Polymerase Chain Reaction,
pubmed-meshheading:1655743-Protein Conformation,
pubmed-meshheading:1655743-RNA, Messenger,
pubmed-meshheading:1655743-RNA Splicing,
pubmed-meshheading:1655743-Rats,
pubmed-meshheading:1655743-Sodium-Potassium-Exchanging ATPase
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform.
|
| pubmed:affiliation |
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|