pubmed-article:1655663 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1655663 | lifeskim:mentions | umls-concept:C0019381 | lld:lifeskim |
pubmed-article:1655663 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
pubmed-article:1655663 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
pubmed-article:1655663 | lifeskim:mentions | umls-concept:C0430420 | lld:lifeskim |
pubmed-article:1655663 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:1655663 | pubmed:dateCreated | 1991-11-21 | lld:pubmed |
pubmed-article:1655663 | pubmed:abstractText | Monoclonal antibodies (MAbs) were developed against immunodominant HHV-6 (GS isolate) late and early proteins. The major late protein was identified as a probable glycoprotein with a molecular weight of approximately 110 kDa (gp 110). Immunoblotting of the early antigen yielded proteins of 41 and 38 kDa (p41/38). The MAb to the early protein reacted with cells infected with 14 different HHV-6 isolates. In contrast, the MAb against the late protein reacted with only 10 of these isolates, indicating that there was strain variation in this glycoprotein. The percentage of antibody-positive sera reactive with gp110 in the ELISA ranged from 56% to 96% among the different serum donor categories. In contrast, only 10-30% of the sera were positive for antibodies to p41/38 with the exception of sera from patients with African Burkitt's lymphoma (ABL) and Hodgkin's disease (HD). These antibody patterns denote the presence of active HHV-6 replication in patients with ABL and HD. | lld:pubmed |
pubmed-article:1655663 | pubmed:language | eng | lld:pubmed |
pubmed-article:1655663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1655663 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1655663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1655663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1655663 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1655663 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1655663 | pubmed:month | Oct | lld:pubmed |
pubmed-article:1655663 | pubmed:issn | 0020-7136 | lld:pubmed |
pubmed-article:1655663 | pubmed:author | pubmed-author:LevineP HPH | lld:pubmed |
pubmed-article:1655663 | pubmed:author | pubmed-author:PearsonG RGR | lld:pubmed |
pubmed-article:1655663 | pubmed:author | pubmed-author:IyengarSS | lld:pubmed |
pubmed-article:1655663 | pubmed:author | pubmed-author:AblashiDD | lld:pubmed |
pubmed-article:1655663 | pubmed:author | pubmed-author:NeequayeJJ | lld:pubmed |
pubmed-article:1655663 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1655663 | pubmed:day | 21 | lld:pubmed |
pubmed-article:1655663 | pubmed:volume | 49 | lld:pubmed |
pubmed-article:1655663 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1655663 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1655663 | pubmed:pagination | 551-7 | lld:pubmed |
pubmed-article:1655663 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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pubmed-article:1655663 | pubmed:year | 1991 | lld:pubmed |
pubmed-article:1655663 | pubmed:articleTitle | Sero-epidemiological investigations on human herpesvirus 6 (HHV-6) infections using a newly developed early antigen assay. | lld:pubmed |
pubmed-article:1655663 | pubmed:affiliation | Department of Microbiology, Georgetown University Medical Center Washington, DC. | lld:pubmed |
pubmed-article:1655663 | pubmed:publicationType | Journal Article | lld:pubmed |
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