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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-11-21
|
| pubmed:abstractText |
Monoclonal antibodies (MAbs) were developed against immunodominant HHV-6 (GS isolate) late and early proteins. The major late protein was identified as a probable glycoprotein with a molecular weight of approximately 110 kDa (gp 110). Immunoblotting of the early antigen yielded proteins of 41 and 38 kDa (p41/38). The MAb to the early protein reacted with cells infected with 14 different HHV-6 isolates. In contrast, the MAb against the late protein reacted with only 10 of these isolates, indicating that there was strain variation in this glycoprotein. The percentage of antibody-positive sera reactive with gp110 in the ELISA ranged from 56% to 96% among the different serum donor categories. In contrast, only 10-30% of the sera were positive for antibodies to p41/38 with the exception of sera from patients with African Burkitt's lymphoma (ABL) and Hodgkin's disease (HD). These antibody patterns denote the presence of active HHV-6 replication in patients with ABL and HD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
551-7
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:1655663-AIDS-Related Complex,
pubmed-meshheading:1655663-Adult,
pubmed-meshheading:1655663-Antibodies, Monoclonal,
pubmed-meshheading:1655663-Antigens, Viral,
pubmed-meshheading:1655663-Burkitt Lymphoma,
pubmed-meshheading:1655663-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1655663-Fatigue Syndrome, Chronic,
pubmed-meshheading:1655663-Fluorescent Antibody Technique,
pubmed-meshheading:1655663-Herpesviridae Infections,
pubmed-meshheading:1655663-Herpesvirus 6, Human,
pubmed-meshheading:1655663-Hodgkin Disease,
pubmed-meshheading:1655663-Humans,
pubmed-meshheading:1655663-Infectious Mononucleosis,
pubmed-meshheading:1655663-Molecular Weight,
pubmed-meshheading:1655663-Reference Values,
pubmed-meshheading:1655663-Serologic Tests,
pubmed-meshheading:1655663-Viral Proteins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Sero-epidemiological investigations on human herpesvirus 6 (HHV-6) infections using a newly developed early antigen assay.
|
| pubmed:affiliation |
Department of Microbiology, Georgetown University Medical Center Washington, DC.
|
| pubmed:publicationType |
Journal Article
|