Linked Life Data

16556042

Source:http://linkedlifedata.com/resource/pubmed/id/16556042

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-3-24
pubmed:abstractText
The E-cadherin-beta-catenin complex plays a pivotal role in epithelial cell-cell adhesion and in the maintenance of differentiated adult epithelia. Perturbation of its expression or function is widely involved in tumor progression and metastasis. Recent years have seen a rapid expansion in the understanding of the biology and the clinical relevance of the E-cadherin adhesion complex in human lung cancer. During human lung cancer progression genomic, transcriptional and post-transcriptional alterations of the E-cadherin-beta-catenin adhesion system are implicated and comprise deletion of the chromosomic region 3p21 that comprise the locus of the gene encoding beta-catenin, transcriptional downregulation of E-cadherin, cytoplasmic redistribution, phosphorylation of both proteins and proteolysis of E-cadherin. E-cadherin-inactivating mutations and oncogenic-activating mutation of beta-catenin are not reported.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1479-6694
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
649-60
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The E-cadherin-beta-catenin complex and its implication in lung cancer progression and prognosis.
pubmed:affiliation
University Hospital, Department of Pathology, INSERM Unit U578, University Hospital, BP 217, Grenoble, France.
pubmed:publicationType
Journal Article, Review