Linked Life Data

16555825

Source:http://linkedlifedata.com/resource/pubmed/id/16555825

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-3-24
pubmed:abstractText
The work describes the efficient double conjugate addition of ethane and propane dithiols in the presence of sodium methoxide to a wide variety of propargylic carbonyl containing compounds. The products of these reactions are differentiated, 1,3-dicarbonyl systems useful for various synthesis programs. By judicious use of hydroxylated substrates tandem cyclization occurs to afford tetrahydropyran lactols or, in the case of hydroxy-substituted propargylic esters, lactones. The corresponding amino-substituted propargylic aldehydes gives piperidine derivatives upon double conjugate addition tandem cyclization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3263
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2715-25
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds.
pubmed:affiliation
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't