Linked Life Data

16555684

Source:http://linkedlifedata.com/resource/pubmed/id/16555684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-3-24
pubmed:abstractText
Therapeutic stimulation of blood vessel growth (angiogenesis) and vessel enlargement (arteriogenesis) has potential in the treatment of ischemic heart and limb diseases. Numerous experiments have been performed involving the delivery of angiogenic factors, or the genes that encode them, to animal disease models, with generally positive results. Although the results of controlled clinical trials have frequently not lived up to expectations, some have demonstrated limited, but significant, improvements. This review covers the transition of therapeutic angiogenesis approaches from preclinical to clinical studies, describes potential problems in the interpretation of the clinical data, and discusses alternative strategies for the treatment of ischemic diseases using endogenous regulation or delivery of progenitor cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1472-4472
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
A balancing act: therapeutic approaches for the modulation of angiogenesis.
pubmed:affiliation
Department of Medicine, Division of Cardiology, University of California, San Francisco 94143-0124, USA. matt.springer@medicine.ucsf.edu
pubmed:publicationType
Journal Article