Linked Life Data

16554130

Source:http://linkedlifedata.com/resource/pubmed/id/16554130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2006-11-30
pubmed:abstractText
The post-mortem redistribution of a number of psychiatric drugs was investigated. A portion of liver, the gastric contents and blood collected from heart and femoral sites was obtained from 13 cases and analyzed by liquid chromatography-mass spectrometry. Drugs detected included five selective serotonin reuptake inhibitors; venlafaxine, a serotonin/noradrenaline reuptake inhibitor; and risperidone, an atypical antipsychotic. Heart blood concentrations were significantly higher (3.4-fold on average) than those measured in femoral blood when results from all drugs were included together. The range for parent drug concentrations in these two blood specimens was 0.5-6.2. There was no significant correlation of the post-mortem interval, the liver concentration and content of drugs in the gastric contents to the heart:femoral blood concentration ratio. These data serve to demonstrate that variable increases in blood concentration occur post-mortem and limit the interpretative value of such toxicological data.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0379-0738
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
164
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-9
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
The redistribution of selected psychiatric drugs in post-mortem cases.
pubmed:affiliation
Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Southbank, VIC, Australia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.