Linked Life Data

16553294

Source:http://linkedlifedata.com/resource/pubmed/id/16553294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-3-23
pubmed:abstractText
There are little data on the properties of ion channels in the inner nuclear membrane of lymphocytes, though the transport system between cytoplasm and karyoplasm is of a great importance for a complex genetic regulation in these cells. Using the patch-clamp technique we have investigated ion channels of the inner membrane of nuclei isolated from cultured T-lymphoblasts. Our research has shown that there are anionic (370 pS) and cationic (152 pS) channels on the inner nuclear membrane. The latter were characterized by fast kinetics and rapid fluctuations; they had high open probability and were inactivated at large negative potentials. These channels were permeable for K+ and Na+, but impermeable for Cl-. The physiological role of the channels is not clear, but they may play an important role in the ion balance between the cytoplasm and the lumen of the endoplasmatic reticulume of the cell.
pubmed:language
ukr
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[New cation channel of the T-lymphocyte nuclear membrane].
pubmed:publicationType
Journal Article, English Abstract