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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-11-21
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M62843,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M81934,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82983,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82984,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82985,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82986,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82987,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82988,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82989,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M82990,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S60140
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pubmed:abstractText |
A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1655278-Amino Acid Sequence,
pubmed-meshheading:1655278-Animals,
pubmed-meshheading:1655278-Antigens, Neoplasm,
pubmed-meshheading:1655278-Base Sequence,
pubmed-meshheading:1655278-Brain,
pubmed-meshheading:1655278-Carcinoma, Small Cell,
pubmed-meshheading:1655278-Cloning, Molecular,
pubmed-meshheading:1655278-Drosophila,
pubmed-meshheading:1655278-Encephalomyelitis,
pubmed-meshheading:1655278-Gene Expression,
pubmed-meshheading:1655278-Hu Paraneoplastic Encephalomyelitis Antigens,
pubmed-meshheading:1655278-Humans,
pubmed-meshheading:1655278-Lung Neoplasms,
pubmed-meshheading:1655278-Lymphocytes,
pubmed-meshheading:1655278-Molecular Sequence Data,
pubmed-meshheading:1655278-Nerve Tissue Proteins,
pubmed-meshheading:1655278-Paraneoplastic Syndromes,
pubmed-meshheading:1655278-RNA, Messenger,
pubmed-meshheading:1655278-RNA-Binding Proteins,
pubmed-meshheading:1655278-Recombinant Fusion Proteins,
pubmed-meshheading:1655278-Ribonucleoproteins,
pubmed-meshheading:1655278-Sequence Homology, Nucleic Acid
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pubmed:year |
1991
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pubmed:articleTitle |
HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.
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pubmed:affiliation |
Laboratory of Molecular Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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