|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-7-6
|
|
pubmed:abstractText |
B cells may be implicated in the pathophysiology of chronic graft-versus-host disease (GVHD), as evidenced by antibody production against sex-mismatched, Y chromosome-encoded minor HLA antigens in association with chronic GVHD. We therefore designed a phase 1/2 study of anti-B-cell therapy with rituximab in steroid-refractory chronic GVHD. Twenty-one patients were treated with 38 cycles of rituximab. Rituximab was tolerated well, and toxicity was limited to infectious events. The clinical response rate was 70%, including 2 patients with complete responses. Responses were limited to patients with cutaneous and musculoskeletal manifestations of chronic GVHD and were durable through 1 year after therapy. The median dose of prednisone among treated subjects fell from 40 mg/day to 10 mg/day, 1 year after rituximab therapy (P < .001). A chronic GVHD symptom score improved in the majority of treated patients. Antibody titers against Y chromosome-encoded minor HLA antigens fell and remained low, whereas titers against infectious antigens (EBV, tetanus) remained stable or rose during the treatment period. We conclude that specific anti-B-cell therapy with rituximab may be beneficial for patients with steroidrefractory chronic GVHD. This trial was registered at www.clinicaltrials.gov as #NCT00136396.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-10642818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-10666232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-10929168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11090092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11222360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11400948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11509929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11739162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11739201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-11929757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12028061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12036863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12070007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12234170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12651271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12662431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12774054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12877674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-12931119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-14512314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-14725898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15059845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15096539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15103242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15142114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15251978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15529346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15613541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-15897856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-16046530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-16169773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-16239908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-8555508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-9193757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16551963-9827969
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-4971
|
|
pubmed:author |
pubmed-author:AlyeaEdwinE,
pubmed-author:AntinJoseph HJH,
pubmed-author:BienfangDonD,
pubmed-author:CutlerCoreyC,
pubmed-author:HoVincentV,
pubmed-author:KimHaesook THT,
pubmed-author:KlicksteinLloyd BLB,
pubmed-author:LeeStephanie JSJ,
pubmed-author:LevinJesseJ,
pubmed-author:MacdonellRebeccaR,
pubmed-author:MiklosDavidD,
pubmed-author:MillerKatherineK,
pubmed-author:PasekMildredM,
pubmed-author:ReynoldsCarolC,
pubmed-author:RitzJeromeJ,
pubmed-author:SoifferRobertR,
pubmed-author:TreisterNathanielN,
pubmed-author:WooSook-BinSB
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
108
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
756-62
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:16551963-Adult,
pubmed-meshheading:16551963-Antibodies, Monoclonal,
pubmed-meshheading:16551963-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:16551963-B-Lymphocytes,
pubmed-meshheading:16551963-Chronic Disease,
pubmed-meshheading:16551963-Drug Resistance,
pubmed-meshheading:16551963-Female,
pubmed-meshheading:16551963-Graft vs Host Disease,
pubmed-meshheading:16551963-Humans,
pubmed-meshheading:16551963-Male,
pubmed-meshheading:16551963-Middle Aged,
pubmed-meshheading:16551963-Musculoskeletal Diseases,
pubmed-meshheading:16551963-Prednisone,
pubmed-meshheading:16551963-Salvage Therapy,
pubmed-meshheading:16551963-Skin Diseases,
pubmed-meshheading:16551963-Steroids
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Rituximab for steroid-refractory chronic graft-versus-host disease.
|
|
pubmed:affiliation |
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. corey_cutler@dfci.harvard.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
|
