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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-3-22
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pubmed:abstractText |
MV-CEA is an oncolytic measles virus currently being tested in patients with ovarian cancer and whose propagation can be monitored by measuring blood carcinoembryonic antigen (CEA) levels. MV-NIS is an oncolytic measles virus coding for the thyroidal sodium iodide symporter (NIS) whose propagation can be mapped by serial radioiodine imaging. Expression of both CEA and NIS genes from a single virus would combine sensitive, quantitative expression monitoring (CEA) with radioisotopic expression mapping (NIS). Because of the unfavorable replication kinetics of measles viruses expressing both CEA and NIS, we explored the feasibility of combining MV-CEA with MV-NIS for comprehensive virotherapy monitoring in ovarian cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1868-75
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16551872-Animals,
pubmed-meshheading:16551872-Carcinoembryonic Antigen,
pubmed-meshheading:16551872-Cell Line, Tumor,
pubmed-meshheading:16551872-Cercopithecus aethiops,
pubmed-meshheading:16551872-Female,
pubmed-meshheading:16551872-Humans,
pubmed-meshheading:16551872-Iodine Radioisotopes,
pubmed-meshheading:16551872-Kinetics,
pubmed-meshheading:16551872-Measles virus,
pubmed-meshheading:16551872-Mice,
pubmed-meshheading:16551872-Mice, Nude,
pubmed-meshheading:16551872-Oncolytic Virotherapy,
pubmed-meshheading:16551872-Oncolytic Viruses,
pubmed-meshheading:16551872-Ovarian Neoplasms,
pubmed-meshheading:16551872-Recombinant Fusion Proteins,
pubmed-meshheading:16551872-Symporters,
pubmed-meshheading:16551872-Vero Cells,
pubmed-meshheading:16551872-Virus Replication,
pubmed-meshheading:16551872-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
Dual therapy of ovarian cancer using measles viruses expressing carcinoembryonic antigen and sodium iodide symporter.
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pubmed:affiliation |
Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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