Linked Life Data

16551715

Source:http://linkedlifedata.com/resource/pubmed/id/16551715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-3-22
pubmed:abstractText
Sex-specific manifestations of disease are most often attributed to differences in the reproductive apparatus or in life experiences. However, a good deal of sex differences in health issues have their origins in the genes on the sex chromosomes themselves and in X inactivation-the developmental program that equalizes their expression in males and females. Most females are mosaics, having a mixture of cells expressing either their mother's or father's X-linked genes. Often, cell mosaicism is advantageous, ameliorating the deleterious effects of X-linked mutations and contributing to physiological diversity. As a consequence, most X-linked mutations produce male-only diseases. Yet, in some cases the dynamic interactions between cells in mosaic females lead to female-specific disease manifestations.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1538-3598
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1428-33
pubmed:dateRevised
2006-11-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases.
pubmed:affiliation
The McKusick-Nathans Institute of Genetic Medicine and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md 21205, USA. bmigeon@jhmi.edu
pubmed:publicationType
Journal Article