Source:http://linkedlifedata.com/resource/pubmed/id/16550974
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-3-22
|
| pubmed:abstractText |
The intention of the present study was to assess immunohistochemically the expression of c-erbB receptor family in cervical carcinoma specimens of young women. Simultaneously, HPV was detected in the same specimens using immunohistochemical assays. Seventy-five cervical intraepithelial and invasive cancer specimens were assessed retrospectively. Positive c-erbB-2 immunostaining was revealed in 11.7% of tumor specimens, while for c-erbB-3 and c-erbB-4 receptor the corresponding figures were 32% and 49.3%, respectively. Concerning HPV infection-markers, positive immunostaining was found in 31% of cases, while coilocytes were detected in 64% of patients. The correlation of c-erbB receptor expression with malignant aggressiveness in cervical cancer cells concurs with similar data regarding other neoplasias, thus rendering these receptors an important predictive factor and future therapeutic target.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0392-2936
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-72
|
| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:16550974-Adult,
pubmed-meshheading:16550974-Age Factors,
pubmed-meshheading:16550974-Biopsy, Needle,
pubmed-meshheading:16550974-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:16550974-Female,
pubmed-meshheading:16550974-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16550974-Humans,
pubmed-meshheading:16550974-Immunohistochemistry,
pubmed-meshheading:16550974-Neoplasm Invasiveness,
pubmed-meshheading:16550974-Papillomaviridae,
pubmed-meshheading:16550974-Prognosis,
pubmed-meshheading:16550974-Receptor, erbB-2,
pubmed-meshheading:16550974-Retrospective Studies,
pubmed-meshheading:16550974-Risk Assessment,
pubmed-meshheading:16550974-Sensitivity and Specificity,
pubmed-meshheading:16550974-Uterine Cervical Neoplasms,
pubmed-meshheading:16550974-Viral Proteins
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Immunohistochemical detection of HPV proteins and c-erbB receptors in cervical lesion specimens from young women.
|
| pubmed:affiliation |
Department of Pathology, Patras University Hospital, Rion, Greece.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|