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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1991-10-18
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pubmed:abstractText |
The effects of erythromycin (erythromycin stearate, Erythromycin; CAS 643-22-1) on the bronchial hyperresponsiveness and the functions of lymphocytes and neutrophils were evaluated. Administration of erythromycin to asthmatic patients in a dosage of 600 mg/d for 10 weeks reduced the bronchial hyperresponsiveness measured by histamine inhalation test. Furthermore, incubation with erythromycin for 96 h inhibited the mixed lymphocyte reaction at the concentration of more than 10 mumol/l in a dose-dependent manner, and the value of IC50 was about 30 mumol/l. 2-h incubation with erythromycin showed a weak inhibition to n-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced superoxide production of polymorphonuclear neutrophils (PMNs) at the concentration of more than 30 mumol/l in a dose-dependent manner. 1-h incubation with 1 mumol/l and 100 mumol/l of erythromycin inhibited FMLP-induced chemotaxis of PMNs. The rates of inhibition at the concentration of 1 mumol/l and 100 mumol/l were 29.7% and 41.7%, respectively. Erythromycin thus showed a beneficial effect on bronchial hyperresponsiveness. This effect might be due to the regulation of the inflammatory cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
552-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1654910-Adult,
pubmed-meshheading:1654910-Aged,
pubmed-meshheading:1654910-Asthma,
pubmed-meshheading:1654910-Bronchi,
pubmed-meshheading:1654910-Chemotaxis, Leukocyte,
pubmed-meshheading:1654910-Erythromycin,
pubmed-meshheading:1654910-Female,
pubmed-meshheading:1654910-Histamine,
pubmed-meshheading:1654910-Humans,
pubmed-meshheading:1654910-Lymphocytes,
pubmed-meshheading:1654910-Male,
pubmed-meshheading:1654910-Middle Aged,
pubmed-meshheading:1654910-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:1654910-Neutrophils,
pubmed-meshheading:1654910-Superoxides
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pubmed:year |
1991
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pubmed:articleTitle |
Effect of erythromycin on bronchial hyperresponsiveness in patients with bronchial asthma.
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pubmed:affiliation |
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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