Linked Life Data

16546827

Source:http://linkedlifedata.com/resource/pubmed/id/16546827

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2006-3-20
pubmed:abstractText
SIP24 is, a 24 kDa superinducible protein, is an acute phase protein that is expressed in several tissues and organs and is identified in the human, mouse, and rat genome as lipocalin 2 (lcn2). This study investigated SIP24 expression by the rat uterus just before delivery and during postpartum involution. The distribution and levels of expression of SIP24 and myeloperoxidase (MPO) were compared by Western blot analysis and immunocytochemistry. The SIP24 level was high on day 22 of pregnancy and on days 1 and 2 postpartum, decreased on day 3 postpartum, and declined to low levels similar to those in nonpregnant rats by day 5 postpartum. SIP24 positive cells were identified by immunohistochemistry in the luminal and glandular epithelium on day 22 of pregnancy and on days 1, 2, 3, and 5 postpartum in addition to nonpregnant rats. Immunostaining was intense on day 22 of pregnancy and on days 1 and 2 postpartum. MPO also was identified in uterine tissues by immunohistochemistry. An evaluation of the SIP24 and MPO distribution and levels of expression in the rat uterus is consistent with the hypothesis that SIP24 modulates the neutrophil population by activities such as inducing their apoptosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8207
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-41
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Expression of SIP24 in the peripartum and postpartum rat uterus.
pubmed:affiliation
Faculty of Agriculture, Utsunomiya University, Utsunomiya-shi, Japan. akhariro@yahoo.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't