Linked Life Data

16546420

Source:http://linkedlifedata.com/resource/pubmed/id/16546420

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2006-5-23
pubmed:abstractText
We have carried out an in silico exploration of the genomes of Aspergillus nidulans, Aspergillus fumigatus, and Aspergillus oryzae, and identified components of G-protein/cAMP-mediated signaling. Putative G-protein coupled receptors (GPCRs) were distributed over nine classes. The GPCRs within classes were well conserved among aspergilli but varied in other ascomycetes. As previously observed in A. nidulans and other fungi, three Galpha, one Gbeta, and one Ggamma subunits of G proteins were identified in A. fumigatus, whereas an additional likely non-functional Galpha subunit was present in A. oryzae. While most fungal species had five proteins containing the regulator of G-protein signaling (RGS) domain predicted to participate in attenuation of G-protein signaling, A. fumigatus and A. oryzae had an additional RGS protein (RgsD) related to RgsA of A. nidulans. Genes encoding adenylate cyclase, a regulatory subunit and two catalytic subunits of the cAMP-dependent protein kinase, were also identified in the three aspergilli. Finally, regulators of cAMP signaling including low- and high-affinity phosphodiesterases were identified. Taken together, our data indicate a striking diversity at the GPCR level, but little diversity of components at the G-protein and cAMP-signaling level. This may reflect the abilities of these fungi to adapt to various ecological niches and to integrate diverse environmental cues into highly conserved cellular processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1087-1845
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
490-502
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16546420-Adenylate Cyclase, pubmed-meshheading:16546420-Aspergillus, pubmed-meshheading:16546420-Aspergillus fumigatus, pubmed-meshheading:16546420-Aspergillus nidulans, pubmed-meshheading:16546420-Aspergillus oryzae, pubmed-meshheading:16546420-Computational Biology, pubmed-meshheading:16546420-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:16546420-Genome, Fungal, pubmed-meshheading:16546420-Phosphoric Diester Hydrolases, pubmed-meshheading:16546420-Phylogeny, pubmed-meshheading:16546420-Protein Structure, Tertiary, pubmed-meshheading:16546420-Protein Subunits, pubmed-meshheading:16546420-RGS Proteins, pubmed-meshheading:16546420-Receptors, G-Protein-Coupled, pubmed-meshheading:16546420-Sequence Homology, Amino Acid, pubmed-meshheading:16546420-Signal Transduction
pubmed:year
2006
pubmed:articleTitle
G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.
pubmed:affiliation
Unité Postulante Biologie et Pathogénicité Fongiques-INRA USC 2019, Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't