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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0028925,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243072,
umls-concept:C0243077,
umls-concept:C0679622,
umls-concept:C0917785,
umls-concept:C1883254,
umls-concept:C1955846
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pubmed:issue |
11
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pubmed:dateCreated |
2006-4-24
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pubmed:abstractText |
Oleanolic acid and its synthetic derivatives have been identified as novel inhibitors of glycogen phosphorylase. Within this series of compounds, 4 (IC50 = 3.3 microM) is the most potent GPa inhibitor. Preliminary structure-activity relationships of the oleanolic acid derivatives are discussed.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
|
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pubmed:volume |
16
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2915-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16546381-Animals,
pubmed-meshheading:16546381-Blood Glucose,
pubmed-meshheading:16546381-Cyclization,
pubmed-meshheading:16546381-Enzyme Inhibitors,
pubmed-meshheading:16546381-Glycogen Phosphorylase,
pubmed-meshheading:16546381-Hyperglycemia,
pubmed-meshheading:16546381-Mice,
pubmed-meshheading:16546381-Molecular Structure,
pubmed-meshheading:16546381-Muscles,
pubmed-meshheading:16546381-Oleanolic Acid,
pubmed-meshheading:16546381-Rabbits,
pubmed-meshheading:16546381-Structure-Activity Relationship,
pubmed-meshheading:16546381-Triterpenes
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase.
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pubmed:affiliation |
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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