Source:http://linkedlifedata.com/resource/pubmed/id/16546322
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-8-14
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pubmed:abstractText |
The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1766
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16546322-Animals,
pubmed-meshheading:16546322-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16546322-Humans,
pubmed-meshheading:16546322-Neoplasm Metastasis,
pubmed-meshheading:16546322-Neoplasms,
pubmed-meshheading:16546322-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:16546322-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
The Ets transcription factors of the PEA3 group: transcriptional regulators in metastasis.
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pubmed:affiliation |
UMR 8161, Institut de Biologie de Lille, CNRS/Université de Lille I/Université de Lille II/Institut Pasteur de Lille, BP 447, 1 rue Calmette, 59021 Lille Cedex, France. yvan.delaunoit@ibl.fr
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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