Linked Life Data

1654543

Source:http://linkedlifedata.com/resource/pubmed/id/1654543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-10-24
pubmed:abstractText
The effects of naloxone and naloxonazine (an irreversible mu1 antagonist) administration on fetal breathing movement (FBM) patterns under control, physiologic conditions were studied in 10 fetal lambs with chronically implanted electromyogram electrodes in the diaphragm. Neither naloxone (6 mg/h) nor naloxonazine (34 mg) had any effect on the total number of diaphragmatic electromyogram bursts per hour, mean instantaneous breathing rate, or incidence of breathing. However, naloxonazine caused a more fragmented FBM pattern, as indicated by a significant increase in both the number of apneas and pauses per hour, along with decreased epoch duration. In addition, naloxonazine caused a significant reduction in the stability or regularity of the breathing rate. Naloxone had no effects on the dynamic pattern of the FBM. These results suggest that endogenous opiate peptides play a tonic role at the mu1, receptor to maintain both the continuity and stability of the FBM pattern in late gestation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
202-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The effects of selective mu1 opiate receptor blockade on breathing patterns in the fetal lamb.
pubmed:affiliation
Department of Pharmacology, Cornell University Medical College, New York, New York 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.