| pubmed-article:1654497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1654497 | lifeskim:mentions | umls-concept:C2717940 | lld:lifeskim |
| pubmed-article:1654497 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:1654497 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:1654497 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1654497 | lifeskim:mentions | umls-concept:C1157337 | lld:lifeskim |
| pubmed-article:1654497 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:1654497 | pubmed:dateCreated | 1991-10-23 | lld:pubmed |
| pubmed-article:1654497 | pubmed:abstractText | Tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interferon alpha (IFN-alpha) stimulate hepatic lipogenesis in vivo. We now show that TNF-alpha, IL-1, and IFN-alpha stimulate lipogenesis as measured by the incorporation of 3H-glycerol into triglyceride in cultured HepG2 cells. Incubation of HepG2 cells for approximately 24 hours with TNF or IL-1 was required to see stimulation of lipogenesis, with this effect increasing over the next four days. TNF stimulated lipogenesis by 2.4-fold after 72 hours of incubation, while a 3.5-fold stimulation was seen with IL-1. The half maximal concentration for TNF stimulation of hepatic lipogenesis was 4 ng/mL, while that for IL-1 was 0.3 ng/mL. Cells treated with TNF or IL-1 also showed increased secretion of labeled triglyceride into the media. IFN-alpha stimulated the incorporation of 3H-glycerol into triglyceride by 39% after 72 hour's incubation. In contrast, IFN-gamma had no effect on lipogenesis in HepG2 cells. These data suggest that cytokines can directly stimulate the synthesis of triglycerides in cultured Hep G2 liver cells in vitro. | lld:pubmed |
| pubmed-article:1654497 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1654497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1654497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1654497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1654497 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1654497 | pubmed:issn | 0026-0495 | lld:pubmed |
| pubmed-article:1654497 | pubmed:author | pubmed-author:DinarelloC... | lld:pubmed |
| pubmed-article:1654497 | pubmed:author | pubmed-author:FeingoldK RKR | lld:pubmed |
| pubmed-article:1654497 | pubmed:author | pubmed-author:GrunfeldCC | lld:pubmed |
| pubmed-article:1654497 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1654497 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:1654497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1654497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1654497 | pubmed:pagination | 894-8 | lld:pubmed |
| pubmed-article:1654497 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:meshHeading | pubmed-meshheading:1654497-... | lld:pubmed |
| pubmed-article:1654497 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1654497 | pubmed:articleTitle | Tumor necrosis factor-alpha, interleukin-1, and interferon alpha stimulate triglyceride synthesis in HepG2 cells. | lld:pubmed |
| pubmed-article:1654497 | pubmed:affiliation | Department of Medicine, University of California, San Francisco. | lld:pubmed |
| pubmed-article:1654497 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1654497 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1654497 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1654497 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1654497 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1654497 | lld:pubmed |
