Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-10-22
pubmed:abstractText
The gIII glycoproteins of bovine herpesvirus 1 (BHV-1) and of pseudorabies virus (PRV) are structurally homologous. Both proteins also play preeminent roles in mediating virus attachment to permissive cells. To directly compare the functional relation between these glycoproteins, we constructed a recombinant BHV-1 in which the BHV-1 gIII coding sequence was replaced by the PRV gene homolog. The resultant recombinant virus efficiently expressed PRV gIII and then incorporated it into its envelope. The levels of PRV gIII expression and incorporation were equivalent to those achieved by the wild-type virus for BHV-1 gIII. The recombinant virus was fully susceptible to neutralization by anti-PRV gIII neutralizing antibody. In addition, the virus attachment and penetration functions, as well as the virus replication efficiency, which were lost by deleting the BHV-1 gIII gene, were restored by expressing the PRV gIII homolog in its place. These results demonstrated that PRV gIII and BHV-1 gIII share complementary functions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-1847442, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2109039, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2152816, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2159526, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2159532, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2161053, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2161054, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2426466, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2463822, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2535752, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2545907, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2548334, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2554578, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2836609, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2839688, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2846873, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-2991570, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-3009851, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6090566, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6090699, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6092679, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6290536, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6306279, http://linkedlifedata.com/resource/pubmed/commentcorrection/1654451-6377683
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5553-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Pseudorabies virus gIII and bovine herpesvirus 1 gIII share complementary functions.
pubmed:affiliation
Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada.
pubmed:publicationType
Journal Article, Comparative Study