Source:http://linkedlifedata.com/resource/pubmed/id/16543589
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2006-4-27
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| pubmed:abstractText |
In compliance with institutional regulations for care and use of laboratory animals, the aim of this study was to establish and characterize a rodent liver tumor model to provide a platform for preclinical assessment of new diagnostic and therapeutic strategies. A rhabdomyosarcoma tumor was implanted in the right and left liver lobes of 20 rats, for a total of 40 tumors. T1- and T2-weighted magnetic resonance (MR) images, diffusion-weighted images, and dynamic susceptibility contrast agent-enhanced perfusion-weighted images were obtained up to 16 days after tumor implantation and were compared with postmortem three-dimensional computed tomographic (CT) images, digital microangiograms, and histopathologic findings. Fifteen tumors were examined with proton ((1)H) MR spectroscopy. All tumors grew, with a mean volume doubling time of 2.2 days +/- 0.9 (standard deviation) and a final size of 591 mm(3)+/- 124. The rhabdomyosarcoma tumor showed hypervascularity at MR imaging, three-dimensional CT, microangiography, and histologic analysis. On dynamic susceptibility contrast-enhanced perfusion-weighted images, the maximum signal intensity decrease differed in time and extent between the tumor and the liver, with a significantly (P < .001) higher relative blood volume, relative blood flow, and permeability value in the tumor than in the liver. With (1)H MR spectroscopy, the rhabdomyosarcoma tumor and the liver featured significant (P < .001) choline and lipid peaks, respectively. Implantation of a rhabdomyosarcoma tumor in the livers of rats is feasible and reproducible, and this animal model seems promising for future testing of new diagnostic and therapeutic strategies.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0033-8419
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| pubmed:author |
pubmed-author:BosmansHildeH,
pubmed-author:CoudyzerWalterW,
pubmed-author:De KeyzerFrederikF,
pubmed-author:LanduytWillyW,
pubmed-author:LaxYY,
pubmed-author:MarchalGuyG,
pubmed-author:NiYichengY,
pubmed-author:PeetersRonaldR,
pubmed-author:SunXiheX,
pubmed-author:Van HeckePaulP,
pubmed-author:VandecaveyeVincentV,
pubmed-author:YuZ PZP
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| pubmed:copyrightInfo |
(c) RSNA, 2006.
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| pubmed:issnType |
Print
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| pubmed:volume |
239
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
554-62
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| pubmed:meshHeading |
pubmed-meshheading:16543589-Angiography,
pubmed-meshheading:16543589-Animals,
pubmed-meshheading:16543589-Disease Models, Animal,
pubmed-meshheading:16543589-Liver Neoplasms,
pubmed-meshheading:16543589-Magnetic Resonance Imaging,
pubmed-meshheading:16543589-Male,
pubmed-meshheading:16543589-Neoplasm Transplantation,
pubmed-meshheading:16543589-Rats,
pubmed-meshheading:16543589-Rhabdomyosarcoma
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Liver tumor model with implanted rhabdomyosarcoma in rats: MR imaging, microangiography, and histopathologic analysis.
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| pubmed:affiliation |
Department of Radiology and Laboratory of Experimental Radiobiology and Oncology, University Hospitals, Catholic University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
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| pubmed:publicationType |
Journal Article
|