|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2006-4-26
|
|
pubmed:abstractText |
Early detection of prostate cancer (PCa) centers on measurements of prostate-specific antigen (PSA), but current testing practices suffer from lack of specificity and generate many unnecessary prostate biopsies. Soluble urokinase plasminogen activator receptor (uPAR) is present in blood in both intact and cleaved forms. Increased uPAR in blood is correlated with poor prognosis in various cancers, but uPAR has not been shown to be useful in PCa diagnostics. We assessed the ability of immunoassays for specific uPAR forms to discriminate PCa from benign conditions.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0009-9147
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
52
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
838-44
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16543389-Adult,
pubmed-meshheading:16543389-Aged,
pubmed-meshheading:16543389-Diagnosis, Differential,
pubmed-meshheading:16543389-Humans,
pubmed-meshheading:16543389-Immunoassay,
pubmed-meshheading:16543389-Male,
pubmed-meshheading:16543389-Middle Aged,
pubmed-meshheading:16543389-Multivariate Analysis,
pubmed-meshheading:16543389-Prostate-Specific Antigen,
pubmed-meshheading:16543389-Prostatic Hyperplasia,
pubmed-meshheading:16543389-Prostatic Neoplasms,
pubmed-meshheading:16543389-ROC Curve,
pubmed-meshheading:16543389-Receptors, Cell Surface,
pubmed-meshheading:16543389-Receptors, Urokinase Plasminogen Activator,
pubmed-meshheading:16543389-Regression Analysis,
pubmed-meshheading:16543389-Sensitivity and Specificity,
pubmed-meshheading:16543389-Urokinase-Type Plasminogen Activator
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Enhanced discrimination of benign from malignant prostatic disease by selective measurements of cleaved forms of urokinase receptor in serum.
|
|
pubmed:affiliation |
The Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
