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rdf:type |
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lifeskim:mentions |
umls-concept:C0007097,
umls-concept:C0015780,
umls-concept:C0029016,
umls-concept:C0246415,
umls-concept:C0332466,
umls-concept:C0549183,
umls-concept:C0871261,
umls-concept:C1522449,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:dateCreated |
2006-5-4
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|
pubmed:abstractText |
Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15;19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy. The t(15;19) results in the fusion oncogene BRD4-NUT. Information concerning treatment of this rare disorder is scarce.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16542442-Adult,
pubmed-meshheading:16542442-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16542442-Back Pain,
pubmed-meshheading:16542442-Carcinoma,
pubmed-meshheading:16542442-Chromosomes, Human, Pair 15,
pubmed-meshheading:16542442-Chromosomes, Human, Pair 19,
pubmed-meshheading:16542442-Combined Modality Therapy,
pubmed-meshheading:16542442-Epidural Space,
pubmed-meshheading:16542442-Fatal Outcome,
pubmed-meshheading:16542442-Female,
pubmed-meshheading:16542442-Humans,
pubmed-meshheading:16542442-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16542442-Lymphatic Metastasis,
pubmed-meshheading:16542442-Mediastinal Neoplasms,
pubmed-meshheading:16542442-Nuclear Proteins,
pubmed-meshheading:16542442-Oncogene Proteins, Fusion,
pubmed-meshheading:16542442-Polymerase Chain Reaction,
pubmed-meshheading:16542442-Remission Induction,
pubmed-meshheading:16542442-Respiratory Insufficiency,
pubmed-meshheading:16542442-Sepsis,
pubmed-meshheading:16542442-Spinal Neoplasms,
pubmed-meshheading:16542442-Translocation, Genetic,
pubmed-meshheading:16542442-Weight Loss
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pubmed:year |
2006
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pubmed:articleTitle |
Midline carcinoma with t(15;19) and BRD4-NUT fusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy.
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pubmed:affiliation |
Department of Oncology, Lund University Hospital, SE-221 85, Lund, Sweden. jens.engleson@skane.se
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
