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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2006-5-11
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pubmed:abstractText |
In Australia two acellular Bordetella pertussis vaccines have replaced the use of a whole cell vaccine. Both of the licensed acellular vaccines contain the following three components; pertussis toxoid, pertussis filamentous haemagglutinin and the 69 kDa pertactin adhesin. One vaccine also contains pertussis fimbriae 2 and 3. Various researchers have postulated that herd immunity due to high levels of pertussis vaccination might be influencing the makeup of endemic B. pertussis populations by selective pressure for strains possessing variants of these genes, in particular the pertactin gene type. Some publications have suggested that B. pertussis variants may be contributing to a reduced efficacy of the existing vaccines and a concomitant re-emergence of pertussis within vaccinated populations. This study was conducted to survey the pertactin and pertussis toxin subunit 1 types from B. pertussis isolates in Queensland, Australia following the introduction of acellular vaccines.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2334
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16542440-Adolescent,
pubmed-meshheading:16542440-Adult,
pubmed-meshheading:16542440-Alleles,
pubmed-meshheading:16542440-Bacterial Outer Membrane Proteins,
pubmed-meshheading:16542440-Bordetella pertussis,
pubmed-meshheading:16542440-Child,
pubmed-meshheading:16542440-Child, Preschool,
pubmed-meshheading:16542440-Female,
pubmed-meshheading:16542440-Genetic Variation,
pubmed-meshheading:16542440-Humans,
pubmed-meshheading:16542440-Infant,
pubmed-meshheading:16542440-Infant, Newborn,
pubmed-meshheading:16542440-Male,
pubmed-meshheading:16542440-Pertussis Toxin,
pubmed-meshheading:16542440-Pertussis Vaccine,
pubmed-meshheading:16542440-Queensland,
pubmed-meshheading:16542440-Time Factors,
pubmed-meshheading:16542440-Virulence Factors, Bordetella
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pubmed:year |
2006
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pubmed:articleTitle |
Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999-2003.
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pubmed:affiliation |
Public Health Microbiology, Queensland Health Scientific Services, Brisbane, Australia. Shane_Byrne@health.qld.gov.au
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pubmed:publicationType |
Journal Article
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