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pubmed-article:16541315pubmed:abstractTextWe identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.lld:pubmed
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pubmed-article:16541315pubmed:articleTitleBRCA1-positive breast cancers in young women from Poland.lld:pubmed
pubmed-article:16541315pubmed:affiliationDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Po?abska 4, 70-115 Szczecin, Poland. lubinski@sci.pam.szczecin.pllld:pubmed
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