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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-8-9
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pubmed:abstractText |
We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-6806
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pubmed:author |
pubmed-author:BebenekMM,
pubmed-author:BreborowiczJJ,
pubmed-author:ByrskiTT,
pubmed-author:ChosiaMM,
pubmed-author:Domaga?aWW,
pubmed-author:DziubaII,
pubmed-author:FudaliLL,
pubmed-author:Gó?d?SS,
pubmed-author:GórskaJJ,
pubmed-author:Gozdecka-GrodeckaSS,
pubmed-author:GronwallRR,
pubmed-author:GrzybowskaEE,
pubmed-author:Guga?aKK,
pubmed-author:HausOO,
pubmed-author:HoW BWB,
pubmed-author:HuzarskiTT,
pubmed-author:KarczewskaAA,
pubmed-author:KordekRR,
pubmed-author:Koz?owskiWW,
pubmed-author:Kozak-KlonowskaBB,
pubmed-author:KozarFF,
pubmed-author:LamperskaKK,
pubmed-author:LangeDD,
pubmed-author:Lubi?skiJJ,
pubmed-author:MackiewiczAA,
pubmed-author:MakiZZ,
pubmed-author:MierzwaTT,
pubmed-author:Mitu?JJ,
pubmed-author:MorawiecMM,
pubmed-author:MusiatowiczBB,
pubmed-author:NarodS ASA,
pubmed-author:NiepsujSS,
pubmed-author:PosmykMM,
pubmed-author:RozmiarekAA,
pubmed-author:Serrano-FernándezPP,
pubmed-author:SiemsJ LJL,
pubmed-author:SirJJ,
pubmed-author:SorokinDD,
pubmed-author:StawickaMM,
pubmed-author:SurdykaDD,
pubmed-author:SygutJJ,
pubmed-author:SzczylikCC,
pubmed-author:SzwiecMM,
pubmed-author:Uci?skiMM,
pubmed-author:Urba?skiKK,
pubmed-author:WandzelPP,
pubmed-author:Wi?niowskiRR,
pubmed-author:WicksNN,
pubmed-author:WojnarAA,
pubmed-author:ZambranoOO
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pubmed:issnType |
Print
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-6
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pubmed:meshHeading |
pubmed-meshheading:16541315-Adult,
pubmed-meshheading:16541315-BRCA1 Protein,
pubmed-meshheading:16541315-Breast Neoplasms,
pubmed-meshheading:16541315-DNA Mutational Analysis,
pubmed-meshheading:16541315-Female,
pubmed-meshheading:16541315-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16541315-Genes, BRCA1,
pubmed-meshheading:16541315-Genetic Predisposition to Disease,
pubmed-meshheading:16541315-Humans,
pubmed-meshheading:16541315-Middle Aged,
pubmed-meshheading:16541315-Models, Statistical,
pubmed-meshheading:16541315-Mutation,
pubmed-meshheading:16541315-Poland,
pubmed-meshheading:16541315-Prospective Studies
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pubmed:year |
2006
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pubmed:articleTitle |
BRCA1-positive breast cancers in young women from Poland.
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pubmed:affiliation |
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Po?abska 4, 70-115 Szczecin, Poland. lubinski@sci.pam.szczecin.pl
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pubmed:publicationType |
Journal Article
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